产品货号：
GS4453
中文名称：
重组人FGF-19
英文名称：
Recombinant Human Fibroblast Growth Factor-19
产品规格：
5μg
发货周期：
1～3天
产品价格：
询价
分子量：Approximately 21.8kDa,a single non-glycosylated polypeptide chain containing 195 amino acids.
储存条件：冷冻（-20℃）
概述
Human FGF-19 is encoded by the FGF19 gene.FGF-19 belongs to the FGF-19 subfamily which has three members FGF-19,21,23.FGFs are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis.By contrast,the FGF-19 subfamily has recently been shown to function in an endocrine manner.Members of this subfamily have poor ability of binding to heparin binding site which is a crucial factor in ligand-receptor complex formation.β-Klotho has been identified as co-factor required for FGF-19,21,23 signaling.It can obviously increase ligand-receptor affinity.Unlike most FGFs which bind to and activate more than one FGF receptor,FGF19 is a specific ligand for FGF R4.In FGF-19 transgenic mice,reducing liver triglycerides,increasing fatty acid oxidation,reducing glucose levels and improving insulin sensitivity can be observed.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
相关搜索：重组人FGF-19，FGF-19, Human，Recombinant Human Fibroblast Growth Factor-19
储存条件：冷冻（-20℃）
概述
Human FGF-19 is encoded by the FGF19 gene.FGF-19 belongs to the FGF-19 subfamily which has three members FGF-19,21,23.FGFs are classically considered to be paracrine factors and are known for their roles in tissue patterning and organogenesis during embryogenesis.By contrast,the FGF-19 subfamily has recently been shown to function in an endocrine manner.Members of this subfamily have poor ability of binding to heparin binding site which is a crucial factor in ligand-receptor complex formation.β-Klotho has been identified as co-factor required for FGF-19,21,23 signaling.It can obviously increase ligand-receptor affinity.Unlike most FGFs which bind to and activate more than one FGF receptor,FGF19 is a specific ligand for FGF R4.In FGF-19 transgenic mice,reducing liver triglycerides,increasing fatty acid oxidation,reducing glucose levels and improving insulin sensitivity can be observed.
使用说明
This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.
技术规格
| 外观 | Sterile Filtered White lyophilized(freeze-dried)powder. |
| 纯度 | ＞95%by SDS-PAGE and HPLC analyses. |
| 来源 | Escherichia coli. |
| 生物活性 | Fully biologically active when compared to standard.The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 150ng/ml,corresponding to a specific activity of>6.7×103 IU/mg. |
| 成分 | Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4. |
| 内毒素 | Less than 1 EU/μg of rHuFGF-19 as determined by LAL method. |
| 复溶 | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20 ℃.Further dilutions should be made in appropriate buffered solutions. |
| 氨基酸序列 | MRPLAFSDAG PHVHYGWGDP IRLRHLYTSG PHGLSSCFLR IRADGVVDCA RGQSAHSLLE IKAVALRTVA IKGVHSVRYL CMGADGKMQG LLQYSEEDCA FEEEIRPDGY NVYRSEKHRL PVSLSSAKQR QLYKNRGFLP LSHFLPMLPM VPEEPEDLRG HLESDMFSSP LETDSMDPFG LVTGLEAVRS PSFEK |
相关搜索：重组人FGF-19，FGF-19, Human，Recombinant Human Fibroblast Growth Factor-19